During upgrade 'IRX0006I Error running GENHE, line 5: Unmatched "/*" or quote ' error occur while running TSO %GENHE
Component: CA Gen - Host Encyclopedia
The issue is with ISPF concatenation.
CLIST with ISPF was there as if it is a REXX because CEHBCLS0 was in the SYSEXEC at the logon procedure.
Removing the CLIST dealing with ISPF solved the issue.