You upgraded or newly installed Symantec Endpoint Protection Manager (SEPM) 14.3 RU1 or later that used embedded MSSQL Express database.
However, Endpoint Detection and Response (EDR) 4.3 shows "SEPM database error" in [Settings] - [Synapse] - [Enable Symantec Endpoint Protection Correlation] even if you configure Synapse configuration properly.
OS application log of SEPM server shows following error:
Event ID: 17835
Desctiption: Encryption is required to connect to this server but the client library does not support encryption; the connection has been closed. Please upgrade your client library. [CLIENT: <EDR IP address>].
Upgrade Symantec EDR to version 4.5 or later. For detailed information, see Important information about upgrading.