Microsoft .Net framework and WMF on main and distributed landscape servers
Will this have any effect on Spectrum?
Release : 21.2, 22.2
Component : Spectrum Core / SpectroSERVER
Spectrum was never tested with .NET installed or WFM.
However, these should not affect Spectrum in anyway. As long as the ports are available, Spectrum should work just fine.
There are no known issues reported against these.
Side Note: If using the SCOM Connector to integrate with Microsoft's Systems Center Operations Management software, the connector does use/require .net framework.
Install and Run the SCOM Connector