You want to know if you can replace the Microsoft Access Database Engine 2010 that is installed with Symantec Mail Security for Microsoft Exchange (SMSMSE) with Microsoft Access Database Engine 2016. You need to remove anything related to Microsoft Office 2010 due to the MS14-024 vulnerability.
SMSMSE 7.9.1 MP1 (build 22.214.171.124)
SMSMSE 7.10 (build 126.96.36.199)
You can replace the Access Database Engine 2010 with Access Database Engine 2016.
If you receive an error reading "The code execution cannot proceed because VCRUNTIME140.dll was not found.", please install the Microsoft Visual C++ 2015 update available here. Installing this package will resolve the issue.