You are setting up the Symantec Data Loss Prevention Cloud Service for Email, with O365 in Reflecting mode.
But messages are being rejected with various attribution errors.
Release :
Component :
Possible errors on messages as following:
451 4.4.62 Mail sent to the wrong Office 365 region. ATTR35. For more information please go to https://go.microsoft.com/fwlink/?linkid=865268 [SN2NAM02FT002.eop-nam02.prod.protection.outlook.com]
550 5.7.64 TenantAttribution; Relay Access Denied [SN1NAM02FT001.eop-nam02.prod.protection.outlook.com]
These appear to suggest that there is an issue with DNS for your domains in O365, however, it is more likely that there is a problem with the configuration of an Inbound Connector - specifically in regard to the one configured for the DLP Cloud Service for Email.
Verify that the Inbound Connector is setup as per the existing documentation:
In particular, the "550 5.7.64 TenantAttribution; Relay Access Denied" error can indicate that:
Both of the above errors (451 and 550) have also been seen when the Inbound Connector was not configured at all.