SEP clients unenroll in bulk from EDR after SEDR 4.5 replaces self-signed cert during upgrade
+ EDR recently upgraded to EDR 4.5.0
+ EDR had a self-signed certificate for UI.
This issue no longer occurs in 4.6.0 or later. The builds where this issue is fixed are available in the upgrade repository. When you upgrade to EDR 4.6.0 or later, this issue will not occur.
Workaround: Re-import the custom certificate that was previously being used by EDR.