A 14.3 RU1 Symantec Endpoint Protection Manager not work correctly if it was installed on a server without an enabled network adapter.
14.3 RU1
Certificate validation fails during installation because the SEPM installer is unable to get the host name if all network cards are disabled. Viewing the server.crt in the ...\apache\conf folder will show the Issued to and Issued by fields are blank.
Enable at least one network adapter, uninstall the SEPM, then reinstall the SEPM.