The Symantec Endpoint Detection and Response (SEDR) User Interface (UI) reports "SEPM Connection token refresh failed; verify SPEM login credentials". The issue may resolve itself, however will return within a couple of hours.
The token used to by SEDR to access the SEPM is not being refreshed properly.
Option 1 - Remove and refresh the the SEPM token:
Option 2 - Remove the SEPM connection and configure a new connection:
If this symptom happens once every 60 days because the password for the SEPM account expired, changing the password reset interval within SEPM may be needed. See: