macOS kernel panics when SEP/SES (Symantec Endpoint Protection/Security) is installed
There can be various causes for this; please see Resolution section for general troubleshooting and links to specific issues.
Configure your Mac to generate a core dump when the next panic occurs: Apple Technical Note TN2118 - Kernel Core Dumps. Please consult with Apple Technical Support; there may be additional steps necessary for your specific Apple hardware.
If the panics do not occur when SEP is removed, then this is not a SEP issue and you should open a case with Apple support.
Otherwise, enable SEP SymDaemon debug logging per instructions here
After next panic, collect the core dump and also a diagnostic report from the affected Mac: Gathering information about Symantec products on a Mac using GatherSymantecInfo.
Open a case with Symantec at support.broadcom.com/security and upload the GatherSymantecInfo report and any core dump(s) to your case.
Try to isolate the cause of the panic to a specific SEP component or other hardware/software configuration:
# reboot to macOS Recovery Mode and open Terminal window there to perform these steps!
# SIP and macOS system file protections will otherwise interfere
mv NortonForMac.kext SymIPS.kext SymInternetSecurity.kext SymXIPS.kext disabled
# reboot to normal mode; nothing should be listed by "kextstat | grep symantec"
# re-enable kext (again in Recovery Mode) by moving it out of "disabled" folder and rebooting
Report your observations in your support case.