Automic Admin was running into the following problem:
U00050037 SMTP Server '<servername>' replied with Error '530 5.7.57 SMTP; Client was not authenticated to send anonymous mail during MAIL FROM'
The errors in the log showed the following error for the login object as well:
U02001007 User '<username>' is unknown or an invalid password has been provided.
Release : 12.3
Component : AUTOMATION ENGINE
1. Login to client 0000
2. Edit UC_HOSTCHAR_DEFAULT
3. Add the following with a value of Y:
ANONYMOUS_FE, ANONYMOUS_FT, ANONYMOUS_JOB
4. Edit the agent ini and set 'login_check=no'
5. Restart agent