After applying 15.1 Maintenance Patch 2 to your detection servers you start to get the Event in the server logs showing the Error "2920: Failed to load database profile".
The FileReader0.log on the detection server shows the error:
Oct 1, 2019 5:14:05 PM com.vontu.profiles.monitor.loader.ProfileOperationalLogger loadFailed
SEVERE: (DETECTION.302) Failed to load profile [46,477:596][AD EUR SGCIB]
com.vontu.profileindex.IndexException: Failed to load RAM index from D:\Symantec\Data Loss Prevention\Detection Server\15.1\..\..\Server Platform Common\15.1\index
This may be due to following reasons: