If you use Mail Security for Domino with Endpoint Protection 12.1, you must enable LiveUpdate in Mail Security for Domino.  Starting with version 12.1, Endpoint Protection no longer shares virus definitions with other Symantec products.

To enable LiveUpdate in the SMSDOM Settings database

1. In the SMSDOM Settings database, open the server group.
2. On the LiveUpdate tab, under Options, check Enable LiveUpdate.
3. Under Schedule, select the time and frequency that you want.
4. Click Save.