Add the servers internal to the Exchange environment to the list of internal senders in the Exchange transport configuration per Prevent Internal Servers from Being Filtered.
To add servers to the Exchange Hub Transport configuration using Powershell:
Set-TransportConfig -InternalSMTPServers @{add="ip address of server to ignore for spam"}
After performing these steps, SMSMSE Premium Antispam will no longer scan connections coming from the added IP address for spam. These connections will still be scanned for AntiVirus, Content Filtering and File Filtering.
Symantec recommends against adding Front-End servers to this configuration, as this will prevent all connections coming from a Front-End server from being scanned for spam. This behavior is documented in Spam is not detected when Symantec Mail Security for Microsoft Exchange (SMSMSE) is installed on an Microsoft Exchange Edge or Hub server