The Symantec Endpoint Protection Manager directories retain many .TMP folders which are consuming large amounts of disk space.
Symptoms
Definition 12/31/2009 rev. 114 or later can cause this issue on the Symantec Endpoint Protection Manager MR4 MP1 or earlier.
The tmp folders are created when LiveUpdate runs or a .JDB file is dropped on the Symantec Endpoint Protection Manager
Delete the TMP files/folders and migrate the Endpoint Protection Manager to RU5 or later:
References
Security Content for Symantec Endpoint Protection clients and Symantec Endpoint Protection Managers are dated Dec 31 2009 even when using the latest definitions
http://service1.symantec.com/support/ent-security.nsf/docid/2010010308571348