The information from KB 27161 did not seem to apply in this case. In the IIS manager, there were no virtual directories under the main Altiris one, and this one did not point to an actual folder on the computer. This server had previously been installed with the Notification Server software, which was since removed.In the Altiris Agent, the Package Server Agent was not showing up as an installed agent, although the software task showed as being run properly. When a run was attempted on it again, it appeared to run but the Altiris logs showed it was already installed so it didn't attempt the run again.
server: Notification Server 6.0.6074 (SP3 + R6)
Windows 2003 Server
client: Windows 2003 server