When Unified Agent (UA) is on active mode, the users experience a failure to connect to Sharepoint.
Web Security Service
Web Security Service (WSS) is intercepting the Sharepoint traffic and does not recognize some of the URLs it uses for its connection as trustworthy.
Here is a list of additional destination URLs that need to be added to Trusted Destinations for Sharepoint to work properly.
You can access the Trusted Destinations list by doing the following:
Log in to Portal, go to Solutions > Threat Protection > Policy > Trusted Destinations, then input the following URLs: