Low level mapping are somehow impacted and reflecting value in IIS settings.
Error in IE: "This Page can't be displayed" "Make sure the web address' Server name (Not the altiris) is correct' "
So it could not reach the site root in IIS server at all.
Ran command: netstat -anob
Which confirmed that the low level mapping are somehow impacted and reflecting value as 127.0.0.1, instead of 0.0.0.0
Once Root case identified, we tried below command to delete BAD mapping and add the right one.
To see mapping:
netsh http show iplisten
Delete old mapping:
netsh http delete iplisten ipaddress= 127.0.0.1
Add new mapping:
netsh http add iplisten ipaddress=0.0.0.0
Did a server reboot after this.