You noticed that your domain controllers were getting over 300,000 authentication events from the ITMS application credentials per hour (over 9 million in 24 hours). You traced this back to a certs/SSL/HTTPS call on the Site Servers and SMP server.
The Symantec Management Agent (aka Altiris Agent) logs showed lots of entries referring to pages like:
.../Altiris/ClientTaskServer/Register.aspx
.../Altiris/ClientTaskServer/GetTasks.aspx
.../Altiris/ClientTaskServer/PostStatus.aspx
ITMS 8.5 and later
A change had been made to the default settings under the "Default Website>Altiris>ClientTaskServ
The resolution for this issue was: