All users from one location attempting to access a website are receiving Network Error: A communication error occurred: "Connection Refused" on one data pod.  Other locations connecting to different data centers or data pods are able to reach the website.

Network Error

A communication error occurred:
"Connection refused".
This Web Server may be down, too busy, or experiencing other problems preventing it from responding to requests.  You may wish to try again at another time.

The website could be blocking the data center egress IPs.

Bring it to the attention of Symantec Support to confirm. Provide the data center you are connected to. Do this with pod.threatpulse.com.