The Content Filtering tab of the ThreatPulse portal provides a policy editor. You can create a rule regarding times the rule applies. The When column provides this part of the policy. Does the rule apply to the timezone of the creator or the user in their own time zone?

The When setting applies to the time zones of the users in their respective location. For example, the rule triggers at 6:00 PM EST for users on the east coast and 6 PM PST for users on the west coast.