The message indicates that the MAA is either not in working condition or that its queue got long enough that Content Analysis stopped sending files to it. This error message could be more clear, but the problem is that the MAA doesn't have enough resources to process more files while Content Analysis is trying to submit them.
The customer could also check the 'System status' whether its green, yellow or red and check whether the Task Queue, Processor and Storage Space are in good 'health' during the error.
The Content Analysis log can provide more information on the error when Sandboxing logging is set to debugging. You can see the following log when the error is occurring. Note the message prior to the error.
2015-04-16T12:04:12.083288+02:00 cas_1_2-6-x86_64 avservice[4120]: ERROR : SandboxingBCMAA::Authenticate: Code: [28] Timed out: [https://x.x.x.x/rapi/auth/session]
2015-04-16T12:04:12.083547+02:00 cas_1_2-6-x86_64 avservice[4120]: ERROR : SandboxingFile::SubmitJob: Error uploading file TP02660302.cab to Blue Coat Malware Analysis Appliance at x.x.x.x
2015-04-16T12:04:15.714415+02:00 cas_1_2-6-x86_64 avservice[4120]: ERROR : SandboxingBCMAA::SendGetRequest: failed on
https://x.x.x.x/rapi/system/health_stats/queues: 28
2015-04-16T12:04:15.714459+02:00 cas_1_2-6-x86_64 avservice[4120]: ERROR : SandboxingBCMAA::SendGetRequest: failed with HTTP code 0 on
https://x.x.x.x/rapi/system/health_stats/queues2015-04-16T12:04:16.261970+02:00 cas_1_2-6-x86_64 avservice[4120]: ERROR : SandboxingBCMAA::Authenticate: Code: [28] Timed out: [https://x.x.x.x/rapi/auth/session]
2015-04-16T12:04:16.262261+02:00 cas_1_2-6-x86_64 avservice[4120]: ERROR : SandboxingFile::SubmitJob: Error uploading file 42.0.2311.90_41.0.2272.118_chrome_updater.exe?cms_redirect=yes&expire=1429192471&ip=213.164.164.164&ipbits=0&mm=28&ms=nvh&mt=1429178053&mv=m&nh=IgpwcjAxLm1hZDA2KgkxMjcuMC4wLjE&pl=19&shardbypass=yes&sparams=expire,ip,ipbits,mm,ms,mv,nh,pl,shardbypass&signature=152EE869361946A62DF3DF1FB7FFDB0C6020D20F.4FC44E1FE6F2285186185F1442A41DF2732A85DA&key=cms1 to Blue Coat Malware Analysis Appliance at x.x.x.x
2015-04-16T12:04:16.262297+02:00 cas_1_2-6-x86_64 avservice[4120]: ERROR : Sandboxing::Worker: Could not create sandbox object
2015-04-16T12:04:16.262427+02:00 cas_1_2-6-x86_64 avservice[4120]: ERROR : Sandboxing::Worker: Could not create sandbox object
2015-04-16T12:04:23.812202+02:00 cas_1_2-6-x86_64 avservice[4120]: ERROR : Sandboxing::Worker: Could not create sandbox object
2015-04-16T12:04:23.812247+02:00 cas_1_2-6-x86_64 avservice[4120]: ERROR : Sandboxing::Worker: Could not create sandbox object
2015-04-16T12:04:23.812289+02:00 cas_1_2-6-x86_64 avservice[4120]: ERROR : Sandboxing::Worker: Could not create sandbox object
Where x.x.x.x is the MAA IP.