According to IBM documentation, JES2 has only z11 mode on z/OS V2.1 or higher level.
Can CA Top Secret Option for DB2 work in JES2 z11 mode environment without problem?
Yes, CA Top Secret Option for DB2 works fine with z11 mode and no required maintenance level is needed.
CA Top Secret Option for DB2 doesn't depend on the JES2 Checkpoint Mode.