Check the CVE and determine what type of vulnerability it is. Network Protection products will protect against the following:
Example: Research into CVE-2010-2568 (stuxnet) shows a URL being used by stuxnet as www.mypremierfutbol.com. Running this URL through sitereview we get a result of:
If the exploit is file based, CA will be the first line of defense. CA can use one of several AV vendors to check if a file is malicious or not. These AV vendors independently take care of updating signatures and so on. To quickly check if your particular vendor protects against a particular vulnerability, run the following query in google:
CVE-2011-0611 site:virustotal.com
Of course the CVE number can be changed. For example, the first link for the above query gives:
In this case, several of the CA AV Vendors protect against this particular vulnerability.