After upgrading to Encryption Management Server 3.4 or above, hosts that were previously able to connect to the server can no longer do so.
Symantec Encryption Management Server version 3.4 or above with the following attributes:
Encryption Management Server 3.4 and above implements Strict mode Reverse Path Forwarding as defined in RFC 3704. This is used to prevent packets that arrived via one interface from leaving via a different interface. This prevents IP spoofing from local subnets and reduces the opportunity for DDoS attacks.
There are two possible solutions to this issue:
Please contact Symantec Technical Support for assistance with this issue.
Please note that Symantec Technical Support will not be able to define the routes you need but can assist in configuring the routes.
For further information please see this article from Red Hat: