There is a requirement to install Symantec Endpoint Protection (SEP) clients on an Exchange 2016 server. Recommended Microsoft exclusions need to be configured.
Microsoft Exchange Server 2016 and SEP 12.1.x, or SEP 14.x.
Automatic Exclusions for Exchange 2016 has been added in SEP 14.0. In releases of SEP 12.1.x, scan exclusions for Exchange 2016 need to be added manually per Microsoft's recommendations. Please follow the instructions contained in the article "Running Windows antivirus software on Exchange 2016 servers".