IronKey USB Devices do not operate without special configuration when controlling USB device access with Application and Device Control.
IronKey devices have multiple device IDs and specific process whitelist requirements.
Part I: Exceptions Policy
Application Exception - Prevent SONAR interaction and/or process injection upon execution of <cdpart>:\IronKey.exe and <cdpart>:\windows\Ironkey.exe or their dependencies.
Note: After entering an application to monitor it may take a while for new execution attempts to be reported to the SEPM. Repeat steps 1-3 to work with newly detected applications.
Application Control Exception - Prevent process injection upon execution of <cdpart>:\IronKey.exe and <cdpart>:\windows\Ironkey.exe or their dependencies.
Note: There should be two exceptions per expected drive letter. (i.e. d:\ironkey.exe, d:\windows\ironkey.exe or e:\ironkey.exe, e:\windows\ironkey.exe)
The completed policy should look similar to the following. The number of necessary exceptions will vary if older and newer devices are used. If all of the IronKey devices are the same model and revision you should only see 2 File exceptions (Application Control) per drive letter and 2 Application exceptions (The hash won't change with drive letter, however duplicate hashes may be seen if the application was detected in more than one location).
Part II: Application and Device Control Policy
Option 1: Blacklist style with read-only support on regular USB keys (Block writing to USB except IronKey)
Option 2: Whitelist style with all USB storage except IronKey blocked
Note: MTP devices such as newer smartphones may require additional class blocking. (e.g. Portable Device - Class ID: {eec5ad98-8080-425f-922a-dabf3de3f69a})
Additional Troubleshooting:
If an IronKey device is connected to a computer where the USB block policy is in place it will be disabled. Adding the exclusion in device control should re-enable the device. If no drive letters are seen after removing and reinserting the device, check the device manager and confirm it is not in a disabled state. Enable the device if necessary.