The Symantec Endpoint Protection Manager (SEPM) embedded database service is shutting down. The db\err.log file contains many errors with "Checksum failure on page ...".

04/03 16:42:54. *** ERROR *** Assertion failed: 200505 (12.0.1.3554)[sem5]
Checksum failure on page 273125
04/03 16:44:18. *** ERROR *** Assertion failed: 200505 (12.0.1.3554)[sem5]
Checksum failure on page 273125
04/03 16:53:02. *** ERROR *** Assertion failed: 200505 (12.0.1.3554)[sem5]
Checksum failure on page 273125

The database is corrupt. The corruption is likely related to a hardware issue, such as bad blocks or corruption on the physical disk.

• Investigate disk corruption with checkdisk (including a scan for bad sectors using chkdsk/r), and further with tools from the hard drive manufacturer.
• Perform a check of other hardware on the machine, including the memory/RAM.
• Restore the SEPM database from a previous backup.

See also:
Best Practices for Disaster Recovery with the Symantec Endpoint Protection Manager
http://www.symantec.com/docs/TECH160736
 

If there is no database backup, and the SEPM is able to run for a short while before the database service shuts down, then it might be possible to export individual policies (firewall, anti-virus etc.) from the console to re-import on a fresh rebuilt SEPM.