When attempting to deploy changes to the Symantec Mail Security for Microsoft Exchange (SMSMSE) Auto-Protect Settings, the SMSMSE console displays a pop-up error "Unknown error 80004005". Changes appear to deploy successfully despite the error.
UAC is preventing the logged in user from accessing the contents of the HKEY_LOCAL_MACHINE\System\CurrentControlSet\Services\MSExchangeIS\VirusScan\TransportExclusion registry key.
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When launching the SMSMSE console, right click and Select "Run as administrator"
Server 2008 or greater with User Account Control (UAC) enabled.