This page gives best practices for installing Symantec Endpoint Protection for Macintosh (SEP for Mac) on macOS Server (formerly known as Mac OS X Server and OS X Server).
Symantec does not officially support macOS Server; that is, it has not been extensively tested with SEP for Mac. But there are only minor differences between macOS workstations and servers. SEP for Mac should function and scan for threats as expected.
It is recommended that you use the newest SEP version.
Symantec has not tested SEP with Xsan or Xserve RAID. Symantec cannot recommend using SEP for Mac at all in this way.
SEP on macOS Server should not be seen as a replacement for antivirus software on client computers.
To tune performance, configure SEP Auto-Protect to scan only very specific areas of your storage. Target places like the FTP directory, WebDAV directories, Shared Items, and user directories. Do this using the "Scan only in the following folders" option in the SEP Mac Settings, Advanced, Global Scan Options.
Turn off the scanning of compressed files to increase performance.
macOS Server bundles antivirus and antispam with the mail service. If you enable mail service, make sure that this directory is not scanned:
Additional information can be found in Mac compatibility with the Endpoint Protection Client.