I noticed in the Profile that the authentication password and privacy password are blank. If I update them they look OK and I successfully save it but if I click on another profile and then click back on the profile I just updated it's blank again.
The Priv password is being updated using the following format:
Starting in Spectrum 10.2.2, the format "[3DES|AES|AES256]^<privpassword>" is no longer valid for SNMPv3 profiles. Spectrum 10.2.2 added a new Radio buttons to the "Edit SNMP v3 Profiles Dialog" as shown here:
Release : 10.3, 10.4
Component : Spectrum Core / SpectroSERVER
Remove the "<prefix>^" part of the passwords, and changes will properly save.