What is misconfigured?
E. 2019-03-20 20:37:54.235+0000 OEE1022: The Outbound Enabler received an unexpected HTTP error status: HTTP/1.1 405 Method Not Allowed Allow: GET, HEAD, OPTIONS, TRACE Content-Type: text/html Server: Microsoft-IIS/10.0 X-Powered-By: ASP.NET Date: Wed, 20 Mar 2019 20:37:54 GMT Connection: close Content-Length: 1293
This is the first time in upgrades we are seeing this.
The issue was the Handler Mappings for the relay server were not correct.
The Execute box was not checked.