You're running a Web Agent, and when you try to log in with Windows Authentication, the Web Agent returns an error 500 to the browser:
https://mymachine.example.com/siteminderagent/ntlm/creds.ntc?CHALLENGE=&SMAGENTNAME="[...]
and you can see in the Web Agent traces : [11/28/2018][07:50:41][20576][104][xxxxxxx.xxxxxxx:227]
[SmNtc::getCredentialsWinNativeAuth][xxxxxxxxxxxxxxxxxxxxxxxxxx][*xxx.xxx.xxx.xxxx][][mymachine.example.com][/]
[][LookupAccountSid failed - 5]
Release:12.8-Single Sign-On-for Business Users-MSP
run –> secpol.msc –> Local Policies –> User Rights Assignment