Yes, with HFSSEC(ON), CA Top Secret controls the access to HFS directories and file and UNIX permissions are ignored.
Please see the doc that documents HFSSEC(ON) at:
https://techdocs.broadcom.com/us/en/ca-mainframe-software/security/ca-top-secret-for-z-os/16-0/administrating/controlling-access-to-the-hierarchical-file-system/hfssec-control-option.html